I had a breat question from Mary in an earlier thread that I wanted to give some airplay:
I watched this on youtube, it was very interesting. I have one question to ask: In one the videos, Cordain says you need inflammation to have cancer. What is meant by this? I know carbs have a proinflammatory effect and I know alot of chronic degenative diseases out there: heart disease, diabetes, obesity, etc. have a chronic low level of inflammation present. Does the inflammation turn on genes in susceptible individuals that will give one cancer, another heart disease, another autoimmune disorder, and etc…? At the age of 32 I developed carpal tunnel, the previous 2 years before I would say glycemic control was slipping, I don’t have an actual blood test but would not be surprised if I had IGT. The actual week that my carpal tunnel really got worse,I purely by coincidence went on the Atkins diet (I went on to lose 40 pounds in the next 5 months). I noticed that it improved over time but went ahead with carpal tunnel release surgery. I did not know at the time that the carpal tunnel was the result of the high blood sugar excursions damaging my nerves. We have rheumatoid arthritis in my family and I am well aware of the fact now that carpal tunnel out of the blue is an herald for RA. I know this is just speculation, but if I avoid inflammation in general, a high glycemic carb diet, to what extent will that decrease the chances of developing RA? My family’s health history includes heart disease, breast cancer, high blood pressure, high triglycerides, overweight not really obese, and few diabetics and as you probably suspect a low carb diet makes a huge difference in my health. I can already guess, that you would probably say to me, considering my family’s background, that a gluten-free, low carb diet for the rest of my life would be the best option.
From The Paleo Diet vs. Multiple Sclerosis, 2008/09/07 at 2:24 PM
So Mary’s final question is essentially “Is the best route to avoiding cancer, autoimmunity and metabolic derangement a gluten free, low carb diet?” to which I’d have to respond a pretty resounding “yes”. We have pretty clear proposed mechanisms for how hyperinsulinism affects cancer propagation:
1-Increased mitosis (cell division) due to increased growth factors such as Insulin Like Growth Factor (IGF) and Epithelial Growth Factor (EGF).
2-Disruption apoptosis (programmed cell death) by disruption in retinoic acid metabolism in the liver.
Add to this what we know about various neolithic lectins and we exacerbate the situation by disruption of insulin signaling and immune function, especially with gluten.
We have proposed mechanisms, cause and effect but not too many people care to look at this stuff because it demonizes the basis of our modern food pyramid instead of fat. Oy-vey!
Mary, you alluded to another piece in all this. Hyperinsulinism and autoimmunity affect different people differently. You are a perfect illustration of how diverse the effects are: Everyone knows Carpal Tunnel is an overwork orthopedic issue, right? Well, no. It’s an inflammatory issue and the surgery prescribed to fix it does little good. A Low carb diet and fish oil (a low inflammation diet) fix the problem completely.
Mary, I REALLY appreciate the question and I wanted to throw out one more thing. In your question you mention that you have a family history of RA, cancer and some other goodies. I’d counter that with this: If go back in your family history, somewhere between 2,000 and 10,000 years your family DID NOT have these diseases. That is your normal birthright because when our ancestors lived as hunter gatherers we simply did not see these diseases.