Chris Kresser – Episode 151

Performance Menu: Journal of Health & Athletic Excellence

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Features guest Chris Kresser

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Robb Wolf’s 30 Day Paleo Transformation

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  1. Ann says

    Chris mentioned a TSH range of 1.8 to 4.0. What is the implication if TSH is 1.45 Free T3 2.2 and free T4 0.9? (cholesterol above 290, TG 56). Female, 35yr.
    Thank you

  2. Jonas says

    Interesting about the lipidprotein functioning as “fatferries”.

    Seem to recall from Dr Lustigs Video The truth about Sugar, that the fructose part of sugar gets turned into fat in the liver.

    Wonder if these two phenomena are related.

    That sugar makes the liver build more fatboats. Thus increasing the total number of fatboats. Contributing to “driving the gradient” and more endothelial damage.

  3. xz123 says

    Just one tiny question from me: For LDL-P values it’s “2000 is bad, 1200 or less is good, 1000 is awesome”, iirc. So what about apoB? Attia wrote that if NMR tests are unavailable one could use apoB as an alternative way to estimate LDL-P, but what is the “good” range here?

  4. Geoff says

    Awesome episode. You guys are saving lives!

    Quick question about the “Mediterranean Paleo” diet that was mentioned. Are white potatoes an acceptable “starchy tuber” for this variant or is there a benefit/reason to stick strictly with yams, sweet potatoes and fruits for the carb content?


  5. Skippy says

    Awesome podcast! Really made sense. We have been Paleo for 2 years (on Oct. 1st, 2012 since reading Robb’s book) and have 2 NMR tests (2011 and 2012)and can’t for the life figure out why LDL-P are so high (1920)!! HDL, Trig, Cholestesterol and HDL-P are all very good. This podcast answered so many questions and gave us direction. Will get Chris’s program for sure. Thyroid and insulin issues also, so can’t wait to figure it all out! Thanks!

  6. Lynn says

    I am one of the 1-2% (Robb’s estimate) who read Peter Attia’s series on cholesterol in totality. I witnessed my late husband having the M.I. in 1998 that took his life. In the years since I have educated myself on health & nutrition in general and heart disease in particular. I really enjoyed Dr. Attia’s posts, but with so much detailed info, I was left wanting a more layman-friendly treatment of this complex subject. I can always count on Chris to explain in a way I can grasp. I also wanted the ever present question, “So, what do I do?” answered. I have purchased Chris’ High Cholesterol Action Plan and will soon dive in to the first installment. Thanks for the excellent insights you both provided, another great podcast!

  7. Stephanie says

    Nice podcast. This will help me when I get my work health screening next week.

    It also reminded me of a talk I saw at work yesterday. (I work at a medical campus, though my Dr. is for physics not med or bio). SCIRO, an Aussie science institute, is currently running a two year long RCT on a low carb low sat fat diet compared to a low fat diet(both with controlled calories and exercise) for people with type 2 diabetes. They did a previous study on low carb vs low fat for type 2 and found lots of good stuff but LDL went up and so did something called FMR that tested something about blood vessels (yep, i’m not a Dr.) and is related to heart badness. So, keep an eye open for their results in a couple of years. It’s not a mediterranian paleo diet but it’s probably as close as you’re going to get out of an RCT until NuSci starts doing some cool stuff someday.

  8. Andrea says

    Great Podcast. Thanks !
    Where is the trannscript? I need it for myself and for other folks who won’t listen to an hour long podcast.

    • Eric says

      Pro Tip: There are plenty of podcast players out there that let you play podcasts at 2x speed. Voila, it’s like you’re reading it! Except you can do other stuff while you listen, like go for a walk!

  9. Chris says

    Ok, what am I missing? D=m/V. When you are talking about LDL and you say “small, dense” it sounds like you’re saying small size as in volume versus small as in mass. But if the volume is small the mass will need to be very small as well to be low density.

    Again, assuming “small” refers to volume, let’s take a generic example. If we say HDL = m/V then relative to HDL and holding mass constant, an LDL particle could be m/(2V). But this means LDL is large compared to HDL. So “samll, dense” better describes HDL and “large, buoyant” describes LDL. In comparison of two objects, if one is buoyant it necessarily has a lower density than the other.

    This has always confused me and I’m just seeking a little clarification, hopefully I described my confusion clearly. In The Great Cholesterol Con, Dr. Malcolm Kendrick has a figure showing the sizes of 5 different lipoproteins and LDL is the largest, beachball resembling one, while HDL is the small BB like protein. If you have that book, take a peek and it should help my question make way more sense.

    I guess the simplest way to describe my confusion is this. When comparing two lipoproteins, LDL=Large, buoyant. HDL=small, dense. But the way I’m understanding your explanations you have these flipped around.

    Can you offer any clarification? I feel like I’m going to cave myself off like the guy in PI and go insane trying to get this clear in my head.


  10. says

    Excellent interview! Thank you for talking about the lipid/thyroid relationship, the numbers & the fact that we are all unique to the possibilities.

  11. says

    This was a fab podcast. In fact the particle size vs particle count discussion was excellent. I also heard Thomas Dayspring talking to Jimmy Moore, and saying the same thing, that LDL particle count is more important.

    There is still a lot of info going around saying particle size is the holy grail, even a recent interview on Dr Oz with Jonny Bowden said size mattered.

    So, the question is, those of us that are moderately educated on this STILL have two differing views. Our doctors probably might not have a clue about either…lol, but I think this needs something of a definitive answer in the near future.

  12. Jeremy says

    I thought I was in great shape after my NMR, considering the ” ..large puffy LDL particles are ok…” consensus, but now wonder how concerned to be over a LDL particle count of ~1500..

    All else is within bounds, as in I don’t exceed any of Kresser’s red flags criteria…Total level to HDL level ratio of just 3, 246/80′, Trigs are just 25…

    Curious of thoughts on this…

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