Detoxing Post Chemo And Radiation Treatment – Episode 176

Performance Menu: Journal of Health & Athletic Excellence

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  1. [5:57] N-Acetyl L-Carnitine Timing And Fasted Training
  2. [9:52] Juicing Yams And Sweet Potatoes
  3. [13:02] Paleo Diet For Athletes Vs. Carb Backloading
  4. [20:27] 5×5 Routines
  5. [28:13] Increase In Child Mortality
  6. [38:27] Detoxing Post Chemo And Radiation Treatment
  7. [50:17] ApoE 4/4 Risk, Diet, And Lifestyle
  8. [1:00:54] Dessert Flavored Vodka


1. n acetyl l carnitine timing and fasted training

Ben says:
Hi Robb and Gregg,

*Insert obligatory message about how awesome you both are.*

First, I should point out that I salute, and whole heartedly agree with Gregg’s grammar-nazism.

I’ve been thinking about trying N Acetyl L-carnitine and ALA as you recommend in your book Robb.

I like to train fasted in the morning. My question is simple: on mornings that I workout, should I take the N Acetyle L-carnitine and ALA before or after training? I have heard that there may be some benefits from a sports/training perspective if taking it before training, is this true? Also, is there any need to cycle these supplements?

Finally, I have heard a bit about n acetyl l cysteine…can you give your views on it?


2. Juicing yams/sweet potatoes

Chris says:
Hi all,

So I started crossfit back in 2006 – but I’m just now trying to commit to the paleo foods and see what happens. Been reading Robb’s book and giving the 30 days a go…

Here is my question – I know post workout yams and sweet potatoes can be ideal – I understand the need for whole foods, but I’m looking at juicing as a better supplementation – so does the nutritional value carryover raw to juiced? (Minus the fiber of course)

Any thoughts on this would be great, and thank you for your time

3. Paleo for Athlete’s vs. Carb back-loading

Jenna says:
I am currently trying to lean out a bit  and am unsure if I should follow a Paleo for Athlete’s approach and include some carb’s in a pre-workout meal or should I adhere to something like carb back-loading?

About me:
-28 year old female
-5’8″, 155 pounds, 25% body fat
– Heavy/high-intensity strength training 3x/week
– 30 min walk in a fasted state 2x/week
– Gymnastics 2x/week
– Seasonal weekend activity for 1-3 hours (currently snow shoeing)

In the near future this will shift and include more swimming/biking/running for the triathlon season.  I am racing in the sprint distance for fun this year and am keeping my cardio activities limited to 4-5 hours/week tops.

What would you recommend to help me reach my fat lost goals and not damage my performance at the same time?

4. 5×5 Confusion

Jeff says:
Hi guys,
I often hear you refer to 5×5 workouts and decided to give them a try.  I never imagined I would find so many opinions regarding a seemingly self-explanatory program design.  Do you prefer the Bill Star approach, Madcow, Rippetow, or one of the many others…and why?


5. Child Mortality

Min says:
Hi Robb
I’ve been following the paleo diet and training crossfit for about 4 years now here in Australia and I’ve read and listened to alot of podcasts etc about the paleo way of living and believe in it 100% There is one area I can’t seem to find much on and thought perhaps you might be able to help. The increase in child mortality over the last 10,000 years since the agricultural revolution we all know has increased enormously. Is there any evidence or someone out there making the connection between the parents and their diet/lifestyle before falling pregnant, during pregnancy which is affecting the child once born. I just don’t understand how children under the age of 10 or even 5 are coming up with cancer. Surely they don’t have the every day stress an adult has these days and if a non paleo lifestyle is leading to these diseases how is the connection being made in someone so young? Basically what I’m asking is could our lifestyles even before conception play havoc once we give birth? Thanks

6. Detox Post Chemo/Radiation in 3 weeks

Adam says:
Hey Robb and Greg. Love the show. Love the info. You guys are great. Yada yada yada.

My girlfriend had 90% of a large tumor removed from her brain in November and is currently undergoing both chemo and radiation treatments to “take care” of the remaining 10%. She was diagnosed with a tumor containing both gliomas and astrocite cells. Those are new words to me so I’m not as familiar with them as I’d like, but I’m sure it is something you know a little about.

My concern is this: What would be your recommended protocol to help her body detox after this treatment is over. She is receiving focused radiation 5 days a week and taking Temodar everyday, both for a 6-week span. She is halfway through and I want to help make sure this junk gets out of her system ASAP. What is your thought on this? Fish oil? Bone broth? Blood of a virgin? Help me out here.

I had her 40 days strict paleo before 3 seizures in a 2-hour period led us to a CT scan that showed us the mass. Then the hospital screwed her up worse than before. I love how processed sugar is assumed to be what EVERY recovering body needs 24/7.

I know a kerogen if approach would probably be helpful, but her radiation doctor said “those diets have great results in studies, but it’s just too hard to do”. ARE YOU KIDDING ME?! We are taking about a tumor in her fucking head, right?

Pardon my language. I look forward to your thoughts, whether my question makes the show or not. Keep up the good work. I just recently got caught up on all the episodes after a year and a half.

7. How somebody with Apo-?4/?4 gene mutation should adapt paleo? (SAVE ME FROM ALZHEIMER AND HEART DISEASE!)

David says:
Dear Robb and Gregg,

Thank you very much for all the work you have done educating people about health and nutrition!

I have a question which might seem to narrow, but in fact applies to 1.7% of population or millions of people.

I would, really, really, really appreciate your help.

I have done 23andme testing and found out that I have a relatively rare mutation in APOE (Apo lipoprotein E) gene. Practically, it means that I have 6 times higher risk to get Alzheimer (which gets me to 40% chance). Basically, I hit both risk alleles. And I hit both twice. A little more information on APOE:

It affects lipid metabolism very strongly.

So, the question is how an APoE 4/4 carrier should eat for optimal health and good lipids?

Some say that they should stop eating saturated fats, because since these carriers can’t utilize fats properly, these become plaque in the arteries and brain (leading to Alzheimer’s or atherosclerosis).

The other half say that because we can’t utilize them properly, we must eat more, otherwise the brain starves. Besides, coconut oil has shown to almost reverse Alzheimer’s in some patients (although we don’t know if these patients were 4/4 or not).

I found one study by Berkeley which seems legit. It strongly support the latter position and recommends that people APOE 4/4 people should minimize saturated fats and even omega-3 as these actually increase LDL (bad cholesterol).

So, how can I get both minimization of Alzheimer’s risk and long-term heart health with healthy cholesterol numbers?

I have followed Paleo diet for quite a while. So I’m wondering how should I adapt it. Research is limited, but from what is available at the moment, I should eat a kind of high-protein, moderate-to-high carb and low-fat Paleo diet?

I also train regularly (weightlifting) and supplement wih a good multiviamin (Pure Encapsulation Nutrient with K2 & methylation complex), Vitamin D3, fish and fermented cod liver oil. Occasionally, cycles of creatine, whey, glutamine, probiotics, Q10, Acetyl-L-carnitine.

What other lifestyle, diet and exercise modifications should I consider to minimize long-term risks both in terms of cariovascular & brain health?

8. Cake Vodka

Angela says:
Hi Robb and Greg,

It’s been a while since I’ve heard anyone ask an alcohol question on this podcast so here goes:  Is cake vodka, or any other dessert flavored vodka, better for someone than eating the actual food (cake, whipped cream, caramel, chocolate, cupcake, atomic hot, etc)?  I drank two of them last night in a standard rocks glass after having a craving for cake that lasted all day long.  Each drink was probably 2 – 3 ounces.  Either way, they quenched my craving for the cake.  I considered the vodka a better option than the real thing, but was it?

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  1. Tim says

    Regarding the issue of Glial tumor and Ketogenic therapy. I am a neurosurgeon and deal daily with these issues. If anyone is interested in utilizing this technique (Which you should), I would recommend that you contact your local childrens hopsital or local pediatric neurology practice. They will typically be able to assist with these protocol that are utilized for pediatric epilepsy. A ketogenic/paleo approach is good. Supplements like Keotcal can aslo be helpful. We are currently working on getting some controlled studies on this topic, but the going is slow. Hope this is helpful!!!



  2. A says

    1. J Nutr Biochem. 2012 Dec 17. pii: S0955-2863(12)00226-4. doi: 10.1016/j.jnutbio.2012.08.009. [Epub ahead of print]

    Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression.

  3. Julie says

    THANK YOU for tackling the APOE E4/E4 diet debate. While we homozygotes are rare; there are literally millions of us “canaries in the coal mines” getting advice from our physicians ranging from very low fat to very high fat in our diets. There is NO consensus.

    I just wanted to throw out the idea that the Paleo diet with regard to this genotype has NOT been tested to my knowledge. Most of the studies out there, never limited carbs- just added or subtracted fat. It would be very interesting to see what a low carb, moderate fat, adequate protein diet does to this genotype. I’m 50 years old and that’s how I eat. My LDL and HDL are both around 85, with my triglycerides around 50. Albeit, I’ve never had an LDL-P, but will soon and report back. Inflammation and glucose markers are all low. I just wanted to caution everyone from presuming dyslipidemia from this genotype

    Also, I liked hearing that our immune systems are stronger (in some senses) that the other genotypes, but wanted to point out that E4’s also have impaired immune systems. Studies reveal that our innate immune systems are indeed overactive (hence the inflammation); with under-active adaptive immune systems leading some to deal with immunodeficiencies.

    Regarding E4’s ability to benefit from ketosis; most studies reveal that we don’t unlike nonE4 carriers. Although the jury may be out on this with anecdotal evidence that some have…

    PLEASE someone consider researching how the Paleo Diet could affect E4’s. You might accidentally cure Alzheimer’s :-)

    The previous questioner pre-supposed a dylipidemia with this

  4. Meesha says

    Regarding the child mortality discussion, I found Weston Price’s work and the Pottenger’s cats studies very informative. They both investigate the connection between parent’s food and their children’s health from generation to generation. But, in general, I agree that there isn’t a ton of data. And I agree it’s most likely our modern environment, whether it’s EMF, flouride in the water, pestacides, processed food, etc. I feel your frustration!!

  5. says

    While listening to this podcast, I gave a sad chuckle to the idea of docs embracing or even mentioning diet. Nine years ago, I was diagnosed with RA. I started seeing a rheumologist and naturopath in hopes they would work together. My rheumatologist refused to take my naturopath’s calls and told me diet hasn’t been shown to work because people can’t stick with it. Well, that only made me more determined to stick with it. I haven’t been able to get off meds without pain and crippling effects, but with diet and working with a naturopath, I was able to reduce medications. Of course my rheumy never acknowledged that diet may have played a part. I have a different rheumatologist today, who says, “Try diet if you want, but we haven’t seen it do much.” Very discouraging for me to have the doctors that are treating you dismiss diet as part of the overall plan.

  6. Jason says

    Robb – You made a claim recently (I believe it was in this episode) about alcohol causing cancer. I confess I’m not up on the research, but can you point to a causal study that demonstrates this? I feel like this is one of the “meat causes cancer” claims that lacks substantiation, but since you always call out the latter on lack of causation, I’m assuming you have something specific here on the link between alcohol and cancer….?

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